GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2275426 | 1 | rs12561806 | chr1:46396776 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.9 | 9.16E-31 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12561806 | chr1:46396776 | MUTYH | chr1:45794915-45806142:- | 0.13 | 4.93 | 9.66E-7 | Body mass index |
| BRCA | cis | rs6684514 | 1 | rs12563631 | chr1:156258953 | BGLAP | chr1:156182784-156213112:+ | 0.2 | 5.47 | 5.73E-8 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12563631 | chr1:156258953 | C1orf85 | chr1:156259882-156265449:- | -0.11 | -3.52 | 0.000447 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs2275426 | 1 | rs12564541 | chr1:46380237 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.87 | 1.37E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12564541 | chr1:46380237 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.54 | 0.000425 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12564541 | chr1:46380237 | MUTYH | chr1:45794915-45806142:- | 0.13 | 5.02 | 5.92E-7 | Body mass index |
| BRCA | cis | rs7537765 | 1 | rs12567136 | chr1:11883731 | CLCN6 | chr1:11866207-11907674:+ | -0.25 | -6.46 | 1.56E-10 | QRS complex (12-leadsum) |
| BRCA | cis | rs12570188 | 1 | rs12570188 | chr10:100855702 | ABCC2 | chr10:101542463-101611662:+ | -0.28 | -3.75 | 0.000189 | Asthma (childhood onset) |
| BRCA | cis | rs12570188 | 1 | rs12570188 | chr10:100855702 | C10orf28 | chr10:99894381-100004653:+ | -0.33 | -4.46 | 9.1E-6 | Asthma (childhood onset) |
| BRCA | cis | rs12570188 | 1 | rs12570188 | chr10:100855702 | COX15 | chr10:101468507-101492423:- | -0.48 | -6.59 | 6.85E-11 | Asthma (childhood onset) |
| BRCA | cis | rs12570188 | 1 | rs12570188 | chr10:100855702 | CUTC | chr10:101491958-101515893:+ | -0.48 | -7.12 | 1.98E-12 | Asthma (childhood onset) |
| BRCA | cis | rs12570188 | 1 | rs12570188 | chr10:100855702 | ENTPD7 | chr10:101419263-101471001:+ | -0.23 | -4.12 | 4.04E-5 | Asthma (childhood onset) |
| BRCA | cis | rs12570188 | 1 | rs12570188 | chr10:100855702 | GOT1 | chr10:101156628-101190530:- | -0.33 | -4.5 | 7.53E-6 | Asthma (childhood onset) |
| BRCA | cis | rs12570188 | 1 | rs12570188 | chr10:100855702 | SLC25A28 | chr10:101370275-101418994:- | -0.37 | -6.61 | 6.07E-11 | Asthma (childhood onset) |